Materials and Methods Ultra-high throughput experimentations were performed using an SPT Labtech Mosquito® liquid handling robot, and the plates were designed by the SPT Labtech Mosquito® plate designer software, nanoChem. Scale-up reactions were conducted in oven- or flame-dried glassware under an atmosphere of nitrogen unless stated otherwise. All reactions were set up in an MBraun LABmaster Pro Glove Box (H2O level <0.1 ppm, O2 level <0.1 ppm). DMSO, diglyme, and xylene were purchased in anhydrous form and were used as received. Reagents were purchased from SigmaAldrich, ThermoFischer Scientific, Alfa Aesar, Oakwood Chemical, TCI Chemical, or Ambeed. All chemicals were used as received. Glass 1-dram (Fisherbrand™ parts No. 03-339-21B) or 2-dram vials (Fisherbrand™ parts No. 03-339-21D) were used as reaction vessels, fitted with standard screwcaps (#03-452-225 or #03-452-300) or with Teflon-coated silicone septa (#CG-4910-02). Magnetic stir bars (Fisher Scientific #14-513-93 or #14-513-65; stirbars.com #SBM-0803-MIC or #SBM-1003-MIC) were used.